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Your Yourlocation: Home > Effects of tiotropium bromide(136310-93-5) combined with salmeterol /formoterol on pulmonary function in elderly patients with stable COPD

To observe the effect of tiotropium bromide(136310-93-5) combined with salmeterol /formoterol on pulmonary function in elderly patients with stable chronic obstructive pulmonary disease (COPD).

Methods: 64 patients with COPD were divided into salmeterol group and formoterol group according to the random number table method. Salmeterol group was given tiotropium bromide inhalant, 1 tablet / time (1 dose per dose of inhalation inhalation), 1 time / d; salmeterol-propofluorophyll powder inhalation, 2 times /d. The patients in the formoterol group were given tiotropium bromide(136310-93-5) inhalants, used in combination with salmeterol; budesonide dermotam powder inhalants, 1 draw /s, 2 times /d. Two groups of patients were treated for 12 weeks. FEV1, the percentage of predicted FEV1%, FEV1 / FVC, and arterial oxygen (HR) were measured in all patients with quality of life, dyspnea and COPD (CAT), first-second forced expiratory volume (FEV1) (IL-6), IL-8, IL-10, tumor necrosis factor (TNF-α) and adverse events in the arterial blood carbon dioxide [pbt (CO2)]. 

Results: After treatment, the three dimensions of life quality, dyspnea and CAT scores, pbt (CO2), IL-6, IL-8, IL-10 and TNF-α were significantly lower than those of the same group FEV1 /FVC and pbt (O2) were significantly higher than those before treatment (P <0.05), and there was no significant difference between the two groups (P> 0.05). The incidence of adverse reactions in the salmeterol group (3.13%) was significantly lower than that in the formoterol group (12.5%), and the difference was statistically significant (P <0.05).

Conclusion: Tiotropium combined with salmeterol /formoterol can significantly reduce the plasma inflammatory cytokine levels, improve the patient's respiratory function and improve the quality of life of patients, but the safety of tiotropium bromide(136310-93-5) combined with salmeterol group is good.

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