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To investigate the protective effect of tiotropium bromide(136310-93-5) on lung injury in rats with smoke inhalation injury.

Methods: Forty-two SD rats were randomly divided into three groups: nurse group (n = 10, no injury), treatment group (n = 16, tiotropium treatment) and control group (n = 16, Not treated with tiotropium bromide). 1 h after injury, the treatment group inhaled tiotropium bromide(136310-93-5) 12μg /mL, 3 mL of saline, the control group inhaled 3 mL of saline, 20 min suction finished. Repeated administration once every 8 h. (IL) -6, IL-10, tumor necrosis factor (TNF) -α were measured after centrifugation, and the left lung, 10% formaldehyde (MPO), malondialdehyde (MDA) and superoxide (MDA) in the supernatant were measured by centrifugation, and the supernatant was used to observe the pathological changes of the rats. Disinfectant enzyme(SOD). Statistical analysis of the values obtained. 

Results: The lung tissue was clear, no congestion, edema, hemorrhage, and focal atelectasis. In the control group, there was obvious congestion, edema, hemorrhage, and focal atelectasis in the lungs. Compared with the control group, congestion, edema, hemorrhage and focal atrophy were reduced. IL-6, IL-10, TNF-α, MPO and MDA in the control group and the treatment group were higher than those in the injury group (P <0.01, SOD was lower than that in the injury group (P <0.01). The levels of IL-10 and SOD in the treatment group were higher than those in the control group (P <0.01).

CONCLUSION: Tiotropium bromide(136310-93-5) can reduce bronchial obstruction and reduce the incidence of atelectasis and /or pulmonary collapse. It can inhibit the release of proinflammatory cytokines IL-6 and TNF-α and promote the release of anti-inflammatory factor IL-10, to reduce the excessive inflammation of the body damage; can also reduce the lung tissue after injury MPO, MDA levels, improve the activity of SOD, with antioxidant effect. Tiotropium bromide has protective effect on lungs with smoke inhalation injury.

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