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Your Yourlocation: Home > Treatment of 21 cases of stable chronic obstructive pulmonary disease by inhalation of tiotropium bromide(136310-93-5) powder

Objective: To observe the effect of inhaled tiotropium bromide(136310-93-5) powder on 24wk in patients with chronic obstructive pulmonary disease(COPD).

Methods: Twenty - one patients with stable COPD were given inhaled tiotropium bromide(136310-93-5) powder, 18μg, once daily for 24wk. The mean values of peak expiratory flow (PEF), mean score of the St. George Respiratory Questionnaire (SGRQ) and the number of acute exacerbations of COPD were measured before and 2, 4, 8, 16 and 24 weeks after treatment.

Results: The mean value of PEF in the treatment of tiotropium was significantly higher than that before treatment(P <0.01). The number of acute exacerbations of COPD was also significantly decreased(P <0.01). The total score of each follow-up SGRQ was more than 4 minutes before treatment.

Conclusion: 18μg of tiotropium bromide(136310-93-5) powder in daily patients with stable COPD has the effect of continuously improving the respiratory function, improving the exercise tolerance and reducing the number of acute attack. The adverse reaction is less and the tolerance is good.

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