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Your Yourlocation: Home > Efficacy of tiotropium bromide(136310-93-5) in the treatment of acute severe asthma

Objective: To investigate the efficacy of tiotropium bromide(136310-93-5) in the treatment of acute severe asthma.

Methods: 72 patients who were not controlled by conventional therapy were randomly divided into observation group and control group(36 cases). The observation group was treated with tiotropium bromide(136310-93-5). The control group was treated with aminophylline to observe the changes of symptoms and signs before and after treatment. After 24 hours of treatment, the peak expiratory flow rate(PEF) and blood gas analysis were recorded and adverse events were recorded.

Results: The total effective rate of the observation group was 94.4%, the clinical symptoms and signs were faster, and the improvement of PEF and blood gas analysis was greater and the difference was statistically significant(P <0.01). Adverse reactions in the control group showed palpitations, 4 cases of vomiting, 4 cases of irritation, 4 cases of dizziness, 2 cases of dizziness; 1 case of dysuria in the observation group, 1 case of dry mouth.

Conclusion: Tiotropium bromide(136310-93-5) has long-term and strong bronchiectasis, and can enhance the curative effect of β2 agonist and less adverse reaction, which provides a new choice for the treatment of acute exacerbation of bronchial asthma.

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