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Your Yourlocation: Home > Application of tiotropium bromide(136310-93-5) combined with high-dose salmeterol /fluticasone in the treatment of severe bronchial asthma with COPD stable period

To investigate the effect of tiotropium bromide(136310-93-5) combined with high dose salmeterol /fluticasone in the treatment of severe bronchial asthma with COPD stabilization.

Methods: 126 patients with severe bronchial asthma complicated with COPD stable phase were selected. The patients were randomly divided into observation group and control group (63 cases). The control group was treated with compound ipratropium bromide aerosol combined with medium dose salmeterol /fluticasone. The treatment group was treated with tiotropium bromide(136310-93-5) powder inhalation combined with high dose salmeterol /fluticasone for 1 year and followed up for 1 year. The changes of pulmonary function before and after treatment were analyzed before and after treatment. The number of acute exacerbations in 1 year, the average acute exacerbation interval during the year, the incidence of adverse reactions, asthma ACT score, quality of life score. 

Results: The scores of the observation group and the control group were better than those before the treatment (P <0.05). The lung function, quality of life score and ACT score of the observation group were better than those in the control group after 1 year (P <0.05). There was no significant difference between the two groups (P> 0.05). There was no significant difference between the two groups (P> 0.05). The incidence of acute exacerbation was less than that of the control group (P <0.05).

Conclusion: Tiotropium bromide(136310-93-5) combined with high dose salmeterol /fluticasone in the treatment of severe bronchial asthma with COPD stable phase can better improve lung function and improve the quality of life, has important clinical value.

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