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Your Yourlocation: Home > Clinical observation of tiotropium bromide(136310-93-5) in the treatment of severe chronic obstructive pulmonary disease

To evaluate the clinical efficacy of Buzhong Yiqi Decoction combined with tiotropium bromide(136310-93-5) in the treatment of severe chronic obstructive pulmonary disease. Methods: Forty patients with stable chronic obstructive pulmonary disease (COPD) were randomly divided into control group and the treatment group of 45 patients in each group, the control group was treated with tiotropium bromide, the treatment group was treated with Buzhong Yiqi Decoction combined with tiotropium treatment, and then the two groups of patients before treatment and 6 weeks after treatment, 12 weeks of lung Function, 6MBWT, acute exacerbation and SGRQ questionnaire. Results: The lung function indexes of the treatment group were better than those of the control group at 6 weeks and 12 weeks after treatment, 6MBWT was larger than the control group, the number of acute exacerbations was less than that of the control group, SGRQ questionnaire (P <0.05). Conclusion: The effect of Buzhong Yiqi Decoction combined with tiotropium bromide(136310-93-5) in the treatment of severe chronic obstructive pulmonary disease is better than that of the control group, and the difference is statistically significant (about 0.05). 

Vagal nerve-mediated bronchial spasm is a major disadvantage of airflow obstruction in COPD patients, and the vagus nerve that controls bronchial smooth muscle can cause spastic bronchial smooth muscle relaxation. COPD patients with airway cholinergic nerve tension is increased, so the use of M receptor resistance stear agent can improve the patient's airflow limitation. Tiotropium bromide(136310-93-5) as a new dry powder inhalation preparation, with a strong, specific anti-cholinergic effect, the role of lasting, only once a day medication, clinical application is convenient, so get more widely used in elderly patients with moderate to severe COPD.

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