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To investigate the effect of tiotropium bromide(136310-93-5) combined with budesonide dermotam powder inhalation combined with noninvasive ventilation in the treatment of chronic obstructive pulmonary disease (COPD) complicated with type Ⅱ respiratory failure. Methods: The clinical data of 150 patients with COPD complicated with type Ⅱ respiratory failure were analyzed from January 2011 to January 2014 in Lufeng People's Hospital of Guangdong Province. According to the different treatment measures, 50 cases were treated with conventional treatment group and combination therapy group. The patients in the conventional treatment group were treated with tiotropium bromide(136310-93-5) plus budesonide dermotam powder inhalation combined with noninvasive ventilation. The levels of respiratory rate, heart rate and oxygen partial pressure were observed before and after treatment (group) (FEV1), 1 s forced air volume (HRV / FVC), FEV1 as the percentage of predicted value (FEV1), 1 s forced air volume ratio (FEV1 / FVC) and FEV1 were measured before and after treatment (PEO2) and carbon dioxide partial pressure (PaCO2) (P <0.01). Conclusion: The respiratory rate, heart rate, PaO2 and PaCO2 of the two groups were better than those of the conventional treatment group (t = 7.01, FEV1 / FVC and FEV1% were significantly better than those in the conventional treatment group (t = 11.86,14.59,15.30, all P <0.05). The patients in the combination group were significantly higher than those in the control group (P <0.05). The tracheal intubation rate and mortality were lower in the combined treatment group than those in the conventional treatment group (x2 = 35.29,10.53, all P <0.05) .Conclusion: Tiotropium bromide(136310-93-5) combined with budesonide dermotam powder inhalation combined with noninvasive ventilation in the treatment of COPD with type Ⅱ respiratory failure clinical symptoms improved significantly, good curative effect, worthy of clinical application.

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