Your Yourlocation: Home > The role of tiotropium bromide(136310-93-5) in airway inflammation in COPD rats

To investigate the effects of tiotropium bromide(136310-93-5) on airway inflammation and airway resistance in COPD. Methods: Thirty rats were randomly divided into three groups: group: normal control group: normal feeding for 28 days; model group: 1 d and 14 (1 d and 14 d) for 28 days; treatment group: COPD model was established in the same way as model group and 30 min before daily smok the rats were sacrificed with tiotropium (0.12 mmol / L, 10 min) for 28 days. The lung function was measured before the rats were sacrificed; the left lung BALF was counted and counted. The histopathological examination of HE staining (P <0.01). The airway resistance of BALF and serum IL-8 and leukotriene B4 (LTB4) were measured by ELISA. Results: ①The airway resistance of model group was significantly higher than that of normal control group (P <0.01) (P <0.01), and the airway resistance of the model group was significantly lower than that of the model group (P <0.05). ②The inflammation and emphysema, but the level of neutrophils was significantly higher in the model group than in the model group. ③The total number of cells and neutrophils in the treatment group were significantly lower than those in the model group (P <0.01). Compared with the model group, the levels of IL-8 and LTB4 in the serum and BALF were significantly higher than those in the normal control group (P <0.01). Tiotropium bromide(136310-93-5) can reduce airway inflammation in COPD rats and delay the deterioration of lung function, which may be achieved by inhibiting the release of inflammatory mediators.

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