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Your Yourlocation: Home > Once daily tiotropium bromide(136310-93-5) treatment can reduce COPD patients with hyperinflation and dyspnea during exercise

Studies have shown that once daily tiotropium bromide(136310-93-5) treatment can reduce COPD patients with hyperinflation and dyspnea during exercise, and can improve the patient's exercise tolerance. However, as a muscarinic receptor antagonist, the potential mechanism of tiotropium for the efficacy of COPD in patients with COPD is still not entirely clear. 

In order to understand the improvement of the patient's respiratory center, whether it is related to the above-mentioned efficacy of tiotropium bromide(136310-93-5), from the Guangzhou Medical University First Affiliated Hospital, the National Center for Respiratory Research, Guangzhou Respiratory Diseases Institute Zhong Nanshan research team, conducted a study, suggesting that tiotropium inhalation therapy, can significantly improve the COPD patients with respiratory center drive efficiency. The article was published in the recent "Pulm Pharmacol Ther" magazine.

In this study, 20 patients with severe COPD were randomly divided into the following two groups: (1) no treatment control group (n = 10), the patient's age was 63.6 years, FEV1 was 29.6% predicted; ② inhaled tiotropium bromide treatment group (n = 10), the patient's age was 66.5 years, and FEV1 was 33% predicted. The drug usage, tiotropium 18μg, once a day inhalation, for 1 month. Throughout the study period, all subjects were allowed to continue using their daily medications other than anticholinergics.

The results of this study show that tiotropium inhalation therapy can significantly reduce the respiratory center of patients with COPD at rest and increase the efficiency of respiratory drive in patients. And this can explain that tiotropium bromide(136310-93-5) inhalation therapy can improve the patient's exercise tolerance.

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