Your Yourlocation: Home > Tiotropium bromide(136310-93-5) can significantly benefit patients with severe asthma

Compared with the use of β2 receptor agonists alone, severe asthma attack, plus tiotropium bromide(136310-93-5) can reduce the risk of hospitalization and improve respiratory function. However, in chronic asthma treatment, the diastolic bronchus of tiotropium does not appear to be as strong as the β2 agonist. Therefore, the application of tiotropium in asthma has not yet been fully elucidated.

In order to clarify the efficacy and safety of tiotropium bromide in the treatment of asthma, Rodrigo and Rodríguez, scholars from the las Fuerzas Armadas Center Hospital in Montevideo, Uruguay, conducted a study showing that tiotropium bromide(136310-93-5) can be effectively improved Asthma patients with pulmonary function, to reduce acute exacerbations in patients with severe asthma. The article was published in the recently published Chest magazine.

A total of 13 randomized, placebo-controlled studies were conducted in 4966 subjects. The main indicators were FEV1 peak and valley values, and diurnal peak expiratory flow (PEF).

The study found that tiotropium bromide as an inhaled glucocorticoid (ICS) adjuvant therapy, can significantly improve PEF (22-24L / min) and FEV1 (140-150mL) levels. In addition, tiotropium can reduce the incidence of acute exacerbation of asthma, improve asthma control levels. The efficacy of tiotropium in patients treated with moderate to high doses of ICS was still not inferior to salmeterol.

Tiotropium bromide as an ICS / salmeterol combination therapy can improve the patient's lung function classification, reduce the number of acute exacerbations of asthma, improve asthma control, and well tolerated and safe.

The study found that tiotropium bromide(136310-93-5) was superior to placebo in patients with moderate to severe asthma with ICS or ICS / salmeterol, poorly controlled symptoms, and was not inferior to salmeterol. The main advantage of tiotropium bromide(136310-93-5) treatment is the ability to improve lung function and reduce the number of acute exacerbations, and more severe asthma patients benefit from it.

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