Your Yourlocation: Home > Asian COPD patients with ammonium use Respimat low doses of inhaled tiotropium bromide(136310-93-5) are at high risk

Tiotropium bromide(136310-93-5) is an inhaled long-acting anticholinergic bronchodilator that can be used once a day for patients with chronic obstructive pulmonary disease (COPD) maintenance therapy.

TIOSPIR trial is a large-scale, long-term, random, parallel, double-blind, dual-simulation event-driven test. The trial evaluated the safety and efficacy of Respimat inhalation of 2.5 or 5 μg of tiotropium bromide(136310-93-5) per day with a daily use of HandiHaler inhaled 18 μg of tiotropium for the treatment of COPD. The study found that daily use of Respimat inhaled 5 μg of tiotropium bromide with daily use of HandiHaler inhaled 18ug tiotropium has similar safety and efficacy.

To further compare the case of the Asian cohort in the trial, the Academician Zhong Nanshan from the Guangzhou Medical University in China conducted an ex post analysis of the Asian population of the TIOSPIR trial, which was published in Respirology.

This study compared the Asian treatment group in the TIOSPIR trial with the rest of the world (RoW) treatment group to assess the safety and efficacy of these regimens in the Asian region.

This study included a total of 2,236 Asian patients, of whom 788 patients were treated with Respimat inhalant tiotropium bromide(136310-93-5) 2.5 μg / day, 774 patients using Respimat inhaled tiotropium 5 μg / day, 797 patients using HandiHaler inhaled tiotrop Bromonium 18ug / day.

The study found that Asian patients using Respimat inhaled 2.5 or 5 μg / day were similar to those used with HandiHaler inhaled tiotropium at 18ug / day of death. Inhalation of 5 μg with Respimat was associated with a risk of acute exacerbation of COPD in patients treated with HandiHaler inhaled 18 g of tiotropium. Using Respimat inhalation of tiotropium bromide(136310-93-5) 2.5 μg of patients, COPD acute exacerbation is higher than the use of HandiHaler inhalation of 18ug patients.

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