Your Yourlocation: Home > Tiotropium bromide(136310-93-5) is a novel anticholinergic drug

Methods: 60 patients with stable COPD were randomly divided into two groups: control group (30 cases): tiotropium bromide(136310-93-5), each time 18ug inhalation, once a day; treatment group (30 cases): tiotropium bromide(136310-93-5) union letter must be paul (160 /4.5ug), each time a suction, 2 times a day, after use, rinse the mouth. The total course of treatment was 24 weeks, and pulmonary function, blood gas analysis and the number of episodes of acute attack were recorded at 12 and 24 weeks before and after treatment.

COPD is characterized by chronic inflammation of the airway, lung parenchyma and pulmonary blood vessels. Chronic inflammation of the small airway wall includes congestion and edema, inflammatory cell infiltration and proliferation of epithelial and fibroblasts, leading to changes in airflow pathways. Mucous gland hyperplasia hypertrophy, thickening of the wall; inflammatory mediator-mediated bronchial spasm, airway wall injury after reconstruction, alveolar wall elastic fiber degradation makes the alveolar retraction force decreased, emphysema after the formation of fine bronchi of the alveolar attachment point decreased, leading to bronchial collapse and so on. Bronchodilator relaxes bronchial smooth muscle, dilates the bronchus, relieves airflow limitation, is the main treatment to control the symptoms of COPD stable treatment.

Tiotropium bromide(136310-93-5) is a new type of anticholinergic drugs, select antagonists for M1 / M3, do not increase the release of acetylcholine, airway smooth muscle on the alkaloid receptor can produce a long time blocking effect, can play long up to 24 hours of long-acting bronchodilator effect. The letter may be glucocorticoid Bu Renai and long-acting β2 receptor agonist limmetil mixed dry powder inhalants, inhaled glucocorticoid Bu Renai can be used in many aspects of inflammation, with a strong anti-inflammatory activity; and it is also highly effective inhaled glucocorticoid, glucocorticoid receptors are highly selective, can be combined with intracellular glucocorticoid receptor to form an active hormone-receptor complex, regulating target cell gene expression, inhibition of inflammatory cell activation and inflammatory factor generation, reduce airway inflammation, with local anti-inflammatory activity and low system activity.

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