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Your Yourlocation: Home > Advances in the study of tiotropium bromide (136310-93-5) in the treatment of asthma or chronic obstructive pulmonary disease

Human lung function M1, M2, M3 cholinergic receptor subtype, M1 and M3 receptor main function for the contraction of the bronchus, M3 receptor can also promote mucin secretion, M2 receptor on the release of choline from the negative feedback regulation effect. Selective M cholinergic blockers are mainly quaternary ammonium, representative of the drug tiotropium bromide(136310-93-5), ipratropium bromide, oxitropium bromide, etc., with a strong polarity, not easily absorbed by the gastrointestinal tract characteristics, it should be made inhalation type. Ipratropium bromide inhalants can selectively block M1 and M3 receptors, duration 4 ~ 6h, but also have a blocking effect on the M2 receptor, so that bronchial dilatation weakened. Tiotropium bromide(136310-93-5) dry powder inhalants, the M1, M3 receptor selectivity, the role of lasting. Mainly for the treatment of COPD, chronic bronchitis and emphysema, is the world's first daily inhalation of COPD drugs.

Asthma is an immune-allergic disease characterized by a variety of factors characterized by reversible airway obstruction, airway hyperresponsiveness, and airway inflammation. The prevalence of asthma is geographically diverse, especially in developed countries, and 10% of children and young people suffer from asthma. According to the 2004 Global Asthma Burden report, about 300 million people worldwide are suffering from asthma, and one out of every 250 deaths is caused by asthma. Another common respiratory disease is chronic obstructive pulmonary disease (COPD), a disease with limited airflow characteristics. Its airflow limitation is not completely reversible and progressively developed, Harmful gases or toxic particles of the abnormal inflammatory response. According to reports, in the United States, COPD is the cardiovascular, tumor and cerebrovascular after the fourth-ranked lethal disease, is expected by 2020, COPD will become the world's third death disease.

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