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Your Yourlocation: Home > Evaluate the efficacy and economy of salmeterol and tiotropium bromide(136310-93-5) in combination with the actual situation in China

As a result of the new selective cholinergic receptor antagonist - tiotropium bromide(136310-93-5), its expansion of bronchial effect was significantly increased, with a specific, strong anticholinergic effect, the role of lasting, only need to inhale once a day, the clinical application is more convenient, Europe and the United States have been approved as COPD stable bronchodilator treatment of first-line medication. In 2013, the latest version of GOLD pointed out that bronchial dilution inhalation therapy is to improve the air flow in COPD patients with limited, shorten the symptoms of shortness of breath the main measures, inhalation of long-acting bronchodilator than the short-term clinical effects of short-term preparation more durable, and more convenient to use LABA is the first choice for the treatment of moderate to severe COPD.

Therefore, this study attempts to evaluate the efficacy and economy of these two regimens by comparing the two drugs for the treatment of COPD: salmeterol and tiotropium bromide(136310-93-5) in combination with the actual situation in China, in COPD control and the choice of treatment means to provide high quality pharmacoeconomic evidence.

With an in-depth study of COPD, researchers have come to realize that vagal-mediated bronchial spasm is a major detrimental factor in COPD, and that inhibition of bronchial smooth muscle vagus nerve can cause spasmodic bronchodilation. Studies have shown that COPD patients with airway cholinergic nerve tension is increased, so the application of LAMA can alleviate the symptoms of COPD patients. Because COPD patients with high vagal tone, a variety of stimuli can stimulate the vagus nerve endings, reflex caused by bronchial spasm, so LAMA in COPD treatment is quite effective. Bronchial dilatation is better than oral theophylline, more secure, especially for those who can not tolerate or hanged β 2 - receptor agonists and theophylline patients.

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