Your Yourlocation: Home > Commonly used tiotropium bromide(136310-93-5) and ipratropium bromide lasting expansion of the bronchus

In traditional COPD medications, bronchodilators and glucocorticoids been in important role. Among them, bronchodilators, especially long-acting β 2 - agonists (LABA) and anticholinergic drugs (LAMA) as a typical representative: long-acting LABA that is first-line drugs, Beeh and other studies have found that patients with COPD inhalation 50 μg twice a day, can effectively reduce the use of short-acting LABA dose, while improving the peak flow rate of morning peak, and little resistance. LAMA has an anticholinergic receptor, so that acetylcholine can not bind to the receptor and show the opposite role with quinoline drugs. LAMA slightly slower than the effect of LABA, but the role of maintenance time was significantly extended, the current commonly used tiotropium bromide(136310-93-5) and ipratropium bromide, through the airway smooth muscle muscarinic receptor on the long-term blocking effect lasting expansion of the bronchus, significantly improve the patient's clinical symptoms and lung function, less systemic adverse reactions. Systemic use of glucocorticoid in patients with acute exacerbation of COPD beneficial, can speed up the remission and recovery of lung function. At present, the domestic market, the main varieties of glucocorticoid Budeside, fluticasone and dipropionate dipropionate and so on.

Chronic obstructive pulmonary disease is a kind of airflow limited characteristics and the air flow is not fully reversible, progressive development, and the lungs of cigarette smoke and other harmful gases or harmful particles of abnormal inflammatory response can prevent and treat disease. In recent years, more and more cities have been affected by haze weather, the disease to the country and patients have brought a great burden, it is necessary to find a more cost-effective treatment program. By reviewing the pharmacokinetic evaluation of tiotropium bromide(136310-93-5) and salmeterol in the treatment of chronic obstructive pulmonary disease, it is found that the cost-effectiveness analysis of these two programs will be very meaningful.

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