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Tiotropium bromide(136310-93-5) is a bronchodilator for the maintenance of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema, maintenance therapy with concomitant dyspnea, and prevention of acute exacerbations. 

Specification: 18 micrograms (equivalent to tiotropium bromide(136310-93-5), equivalent to tiotropium bromide(136310-93-5) monohydrate 22.5 micrograms). 

Dosage: The recommended dose of tiotropium is once daily, and each time a HandiHaler inhalation device is used to inhale a capsule. Tiotropium bromide(136310-93-5) capsules should not be swallowed.

Steps /methods:

1. Pull up on the dust cap. Then open the nozzle. 

2. Remove one capsule from the blister pack (remove it immediately before use) and place it in the central chamber, regardless of the way in which the capsule is placed. 

3. Close the nozzle until you hear a click and keep the dust cap open.

4. Handle the HandiHaler unit so that the nozzle is up, press the green piercing button once and then release it. 

5. Complete breath (first take a deep breath). Note: Whenever you should avoid breathing to the nozzle.

6. Raise the HandiHaler device into the mouth, with your lips tightly covering the nozzle, keep the head vertical, slowly deep breathing, the rate should be enough to hear the capsule vibration. When you inhale the lungs full, hold your breath as long as possible and remove the HandiHaler device from your mouth. Start normal breathing again. Repeat steps 5 and 6 once, the drug in the capsule can be completely aspirated. 

7. Open the nozzle again and pour the used capsule and discard it. Close the nozzle and the dust cap and save the HandiHaler device.

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