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Your Yourlocation: Home > Tiotropium bromide(136310-93-5) is suitable for daily administration to treat stable COPD

Tiotropium bromide(136310-93-5) is a derivative of ipratropium bromide, which is characterized by low systemic absorption with atropine with a positively charged quaternary ammonium structure. The affinity of tiotropium bromide and ipratropium bromide for M1, M2 and M3 receptors was similar, but the dissociation rate of tiotropium bromide(136310-93-5) and M1 and M3 receptors was 100 times slower than that of ipratropium bromide many. The dissociation rate of tiotropium bromide and M2 receptor is greater than that of M1 and M3 receptors, which is more kinetic receptor selectivity for M1 and M3 than M2 receptor, and plays a leading role in its pharmacological action , Its slow dissociation with M1, M3 receptors determines the long-acting properties of tiotropium, which has a strong and lasting bronchodilator and protective effect on COPD patients. At the same time, tiotropium also has anti-inflammatory effect, it keeps the airway open 24 hours, to avoid the airway repeated collapse and open and airway tissue friction, which in itself can prevent the occurrence of airway inflammation. In addition, as with other anticholinergic drugs, can reduce airway secretions, may also inhibit the release of 5-hydroxydecatetraenoic acid cells, inhibition of alveolar macrophages release neutrophils and eosinophil chemotactic activity substances.

Tiotropium bromide(136310-93-5) as a selective anticholinergic bronchodilator, is currently the first long-term M receptor blockers, suitable for daily administration of stable treatment of COPD. Both in improving pulmonary ventilation function, or in improving the quality of life of patients and exercise endurance, have shown a unique advantage in the effective treatment dose did not appear obvious side effects, and thus in the treatment of COPD has broad application prospects. In addition to improving lung function, quality of life and clinical symptoms, tiotropium has a significant effect on 6MWD, but it is still necessary to carry out large-scale, multi-center and prospective studies in clinical practice.

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