Your Yourlocation: Home > Tiotropium bromide(136310-93-5) dry powder inhalants are specific long-acting antagonists

Tiotropium bromide(136310-93-5) powder inhalation is a specific long-acting, selective cholinergic receptor antagonist that binds to the muscarinic M3 receptor on the bronchial smooth muscle to inhibit the choline energy of acetylcholine released by the parasympathetic end role, so as to achieve expansion of the bronchial, reduce the purpose of airway resistance; and can lead the cholinergic nerve glands and goblet cells to reduce mucus secretion, reduce airway inflammation. Thus the drug is commonly used in the clinical treatment of chronic obstructive pulmonary disease. Recent studies have shown that long-term use of β2 receptor agonists in asthmatic patients will reduce the sensitivity of the body to drugs, and long-term use of cholinergic receptor antagonist is no sensitivity to decline. Slat and other studies have found that tiotropium bromide(136310-93-5) can effectively control asthma model airway inflammation, improve the clinical efficacy of asthma. Wang Jingtai reported tiotropium can reduce asthma and serum spleen in the induction of IL13 levels, with anti-inflammatory effect. 

The levels of FEV1, PEF and PaO2 in the treatment group were significantly higher than those in the control group, while PaCO2 and IL8 were significantly lower than those in the control group (P <0.05) group, the difference was statistically significant (P <0.05), children with dry mouth and dysuria may be associated with tiotropium inhibition of smooth muscle M3 receptor, the symptomatic treatment, children were not interrupted treatment, the rest did not see liver and kidney functional damage and serious adverse events. 

The combination of tiotropium bromide(136310-93-5) powder inhalation combined with sulpiride in the treatment of acute bronchial asthma in children can improve the pulmonary ventilation and pulmonary ventilation function and reduce the airway inflammation, which can improve the clinical curative effect without significantly increasing the adverse reaction.

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