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Your Yourlocation: Home > Clinical practice of acute urinary retention induced by tiotropium bromide(136310-93-5) inhalation in 1 case

Tiotropium bromide(136310-93-5) is a new long-term anticholinergic drug with a strong and lasting bronchodilator and protective effect. In recent years, tiotropium has become a first-line drug for the treatment of chronic obstructive pulmonary disease (COPD). The most common adverse reactions were dry mouth (> 10%), usually mild and with continued treatment, the reaction would disappear. Urinary retention was seen in the case of serious adverse events reported in the case of predisposing factors such as prostatic hypertrophy Elderly male patient. In this case, patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) admitted to our hospital respiratory medicine, during the hospital given tiotropium bromide(136310-93-5) inhalation (18μg, inhalation, qd) after treatment of acute urinary retention (AUR), are reported below.

Patients, male, 66 years old, due to "repeated cough and sputum 10 years, chest tightness and shortness of breath 2 years, and then increase to 3d, after admission to give sustained low flow of oxygen, anti-infection (injection of cefodizime sodium) Aminophylline), aerosol inhalation of diastolic airway and other symptomatic treatment, patients with asthma symptoms gradually ease.To consider patients with chronic obstructive pulmonary disease for many years, frequent acute episodes (18μg, qd) diastolic airway, and β2 receptor agonists have synergistic effect, long-term difficult to drug resistance, can improve the patient's pulmonary ventilation function; at 13:00 on January, 13 patients with bladder area pain. To guide the patient to relax the mind, given the patient under the abdomen heat, urination is still not smooth, and finally give indwelling catheter symptoms after remission, line B ultrasound showed: prostate enlargement with calculus or calcification (abdomen), disable tiotropium bromide(136310-93-5), plus with anti-benign prostatic hyperplasia drugs, on January 15 removal of the catheter, the patient can self-urination. (PCO2) 6.90kPa, oxygen partial pressure (PO2) 9.20kPa, the actual bicarbonate (HCO3-) 28, the amount of carbon dioxide .7mmo · L-1. On January 18, patients with cough symptoms were relieved, occasional cough, sputum, cough small amount of white foam sputum, easy to cough up, physical examination: vital signs stable, lung auscultation breath sounds low, can be heard and a little small wet rales. Both lower extremities without edema. Stable condition discharged.


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