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Of the 906 patients who received tiotropium bromide(136310-93-5) for 1 year, the most frequent adverse events were dry mouth. Approximately 14% of patients develop dry mouth. The dry mouth reaction is usually mild and the reaction will disappear with continued treatment.

COPD patients anticholinergic treatment of the most common adverse reactions for dry mouth. Most cases of dry mouth symptoms of mild. In general, dry mouth occurred in the first 3 to 5 weeks after treatment. Symptoms of dry mouth usually disappear after the patient continues to heal. Of the 906 patients who had a 1-year clinical trial, 3 patients (0.3% of the total treated patients) discontinued the trial due to adverse effects of dry mouth. 

In the 1-year clinical trial, severe and persistent adverse events reported in individual cases were constipation and urinary retention. 

Urine retention is only seen in older men with a predisposing factor (eg, prostatic hypertrophy). 

Application of tiotropium bromide(136310-93-5) after individual cases of ventricular tachycardia and atrial fibrillation, usually found in susceptible patients. As with all inhaled therapies, tiotropium bromide(136310-93-5) may cause bronchospasm due to inhalation irritation. Allergic reactions reported by spontaneous adverse reactions include angioedema, rash, rubella and pruritus.

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