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Your Yourlocation: Home > Tiotropium bromide(136310-93-5) has less gastrointestinal absorption, bioavailability is low

Severe acute exacerbation of COPD patients 1 to 3 times each year, each increase is accompanied by increased mortality, lung failure and reduced quality of life, and disease aggravation has become a major part of the annual cost of the disease. Therefore, reducing the frequency and severity of acute exacerbations is also the main goal of treatment of COPD.

In the previous trial, the effect of tiotropium bromide(136310-93-5) on acute exacerbation of COPD was secondary. Compared with the control group or ipratropium bromide group, tiotropium bromide(136310-93-5) group disease exacerbation and hospital treatment rate decreased by 20% to 30% (P <0105). The difference between tiotropium and salmeterol was not statistically significant.

Niewoehner et al. studied 1829 patients with moderate to severe COPD for 6 months and found that patients with tiotropium had lower rates of COPD deterioration (27.9% vs 132.3%, P = 0.037) compared with controls; hospitalizations for deterioration of COPD (710% vs 19.5%, P = 0.056), and tiotropium delayed the first deterioration of COPD patients. The shortcomings of this trial is 99% of the selected object is male patients, and the tracking time is short (6 months).

Similar to ipratropium bromide, tiotropium bromide(136310-93-5) has low gastrointestinal absorption and low bioavailability, and therefore has a wider therapeutic range. The most common adverse events in the trial were dry mouth, typical of anticholinergic reactions, occurring in 10% to 16% of patients. The incidence was slightly higher than that of ipratropium bromide, but the effect was mild , without stopping. The incidence of other serious adverse events was not different from that of the control group. The rate of patient withdrawal for any reason in the trial was similar to that of the control group. Adverse reactions and precautions are similar to ipratropium bromide.

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