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Your Yourlocation: Home > The use of tiotropium bromide(136310-93-5), salmeterol and formoterol these three long-acting inhaled bronchodilators in the treatment of COPD

Comparison of long-acting inhaled bronchodilators: A 6-month, randomized, placebo-controlled, double-blind, double-dummy, parallel-group clinical trial of Donohue et al. In a cohort of COPD patients, (18 μg, once daily, via dry powder inhaler) and salmeterol (50 μg, twice daily, by dosing aerosol). The efficacy of the two drugs was assessed by 12-hour lung function monitoring, dyspnea change index (TDI) and St. George's Respiratory Questionnaire(SGRQ). A total of 623 patients were enrolled in the trial: 209 patients in the tiotropium bromide(136310-93-5) group, 213 in the salmeterol group and 201 in the placebo group. The results showed that bronchodilator effect was greater with tiotropium bromide(136310-93-5) once daily in patients with COPD compared with salmeterol twice daily, with a greater improvement in dyspnea, and a health-related quality-of-life (HRQoL) The proportion of those who had a significant improvement was higher. Tash2kin et al reviewed a large double-blind clinical trial between 1997 and 2003 that briefly described the effects of salmeterol, formoterol, and tiotropium bromide(136310-93-5) on COPD in three long-acting inhaled bronchodilators Summary.

Inhaled corticosteroids inhaled corticosteroids (inhaledcorticosteroids, ICS) has a strong local anti-inflammatory effect, mainly through the following molecular mechanisms to play an anti-inflammatory effect. ICS through the cell membrane into the cytoplasm and its receptor to form glucocorticoid 2 receptor complex, into the nucleus, on the one hand, directly with the glucocorticoid effect elements to improve the release of anti-inflammatory factor or anti-inflammatory mediators; the other hand through the (NF-κB), activator protein 21 (AP21) and so on, which can down-regulate the transcription of many inflammatory factors and reduce the synthesis of proinflammatory cytokines.

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