Your Yourlocation: Home > The efficacy of tiotropium bromide(136310-93-5) combined with sodium aescinate for the treatment of COPD was clear

Tiotropium bromide(136310-93-5) for anticholinergic drugs, not only has specific selectivity, also has muscarinic receptor subtypes M1 ~ M5 is relatively similar affinity. Clinical studies have shown that tiotropium bromide(136310-93-5) with M3 receptor inhibition, bronchodilation, the effective opening of the airway, to alleviate the extent of patients with limited airflow, lung hyper-expansion to reduce, so as to achieve the purpose of improving lung function in patients. 

And in recent years, research results show that tiotropium bromide(136310-93-5) also has a certain degree of anti-inflammatory effect, can reduce the secretion of inflammatory substances and synthesis. Aescinate sodium is a kind of extract from Shorea, clinical pharmacological studies have shown that sodium aescinate can promote prostaglandin F (PGF), adrenocorticotropic hormone (ACTH) synthesis and secretion, thereby enhancing the body PGF, ACTH Anti-inflammatory, enhance the body resistance and so on; the same time, sodium aescinate with the removal of excessive free radicals in the body to improve venous tension, to promote venous blood flow to speed up the anti-inflammatory, anti-inflammatory, , Lower blood viscosity, play a role in improving the body microenvironment. In this study, the authors focused on the clinical efficacy of tiotropium bromide(136310-93-5) combined with sodium aescinate in the treatment of COPD and its effects on airway inflammation and pulmonary function. The results showed that compared with tiotropium alone, the combination of sodium aescinate can significantly improve the clinical symptoms of patients with COPD, blood gas analysis and pulmonary function indicators to improve the degree of more obvious, and TNF-α, IL-6, IL-8 The level of decline is more significant. Thus, tiotropium bromide combined with sodium aescinate treatment of COPD clear effect, worthy of clinical attention.

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