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Tiotropium bromide(136310-93-5) in combination with salmeterol in the treatment of moderate to severe stable COPD patients, the study found that tiotropium combined with salmeterol in the treatment of patients with moderate to severe COPD patients, can be effective Improve lung function, improve oxygen partial pressure, help patients with early recovery, it is worth applying. The article published on "Henan Medical Research".

The aim of this study was to investigate the clinical efficacy of tiotropium bromide(136310-93-5) combined with salmeterol in the treatment of patients with moderate to severe stable chronic obstructive pulmonary disease (COPD).

METHODS: Ninety patients with moderate to severe stable COPD were randomly divided into observation group (n = 45) and control group (n = 45). The patients in the control group were treated with conventional cough and phlegm, anti-infection and oxygen therapy. The patients in the observation group were treated with tiotropium bromide(136310-93-5) combined with salmeterol in the treatment group. The arterial blood was measured before and after the treatment (PaO2), partial pressure of carbon dioxide (PaCO2), forced expiratory volume at 1 second (FEV1), and FEV1 as a percentage of predicted (FEV%).

The results showed that the two groups of patients after treatment blood gas analysis have improved, the observation group to improve more significantly (P <0.05). There was no significant difference between the two groups (P> 0.05). The improvement of the observation group was significant (P <0.05).

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