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The effect of tiotropium bromide(136310-93-5) on pulmonary function and exercise tolerance in moderate and severe COPD patients was studied. It was found that tiotropium powder inhalation has a better clinical efficacy in moderate to severe COPD patients than in the current clinical Bromide aerosol has a more reliable improvement of lung function and exercise tolerance role. The article published on "Chinese Medicine Guide".

The aim of this study was to investigate the effect of tiotropium bromide(136310-93-5) on pulmonary function and exercise tolerance in moderate to severe COPD patients and to evaluate the efficacy of tiotropium in the treatment of moderate to severe COPD.

Methods: Sixty-seven patients with moderate-to-severe COPD were randomly assigned to receive tiotropium bromide(136310-93-5) powder inhalation. The control group was treated with ipratropium bromide aerosol inhalation, and the patients were randomized 1-month clinical treatment. The changes of lung function and exercise tolerance were measured before and after treatment. The results showed that compared with before treatment, the two groups of patients with lung function and exercise tolerance have improved a certain degree. The observation group and the control group, the former improved lung function and exercise tolerance was significantly better than the latter (P <0.01).

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