Your Yourlocation: Home > Effects of tiotropium bromide(136310-93-5) on pulmonary function and blood gas in patients with severe

To observe the efficacy of tiotropium bromide(136310-93-5) in the treatment of severe asthma and its effect on lung function and blood gas. Studies have shown that tiotropium treatment of severe asthma significant effect, can improve patient lung function, and does not increase adverse drug reactions, it is worthy of clinical promotion. The article published on 2014, 18th issue of "Journal of Practical Clinical Medicine".

Forty-four patients with severe asthma were randomly divided into observation group (n = 42) and control group (n = 42). The control group received routine treatment, the observation group on this basis to give tiotropium bromide(136310-93-5) inhalation therapy. The changes of pulmonary function and blood gas analysis were observed before treatment and 6 months after treatment.

The total effective rate was 88.10% in the observation group, which was significantly higher than that in the control group (59.52%) (P <0.01). Compared with the pre-treatment, the forced vital capacity (FVC), forced expiratory volume ), FEV1 (FEV1%) and arterial oxygen partial pressure (PaO2) were significantly increased (P <0.01) and PaCO2 decreased significantly (P <0.01). After treatment, (P <0.01 or P <0.01), PaCO2 was significantly lower than that of the control group (P <0.01). The total adverse reaction rate was 26.19% in the observation group, compared with the control group Group (16.67%), the difference was not statistically significant (P> 0.05).

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