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Your Yourlocation: Home > Effect of tiotropium bromide(136310-93-5) inhalation on moderate and severe COPD patients

To investigate the clinical efficacy of tiotropium bromide(136310-93-5) inhalation in the treatment of moderate to severe stable chronic obstructive pulmonary disease (COPD). Studies have shown that tiotropium can effectively improve COPD patients with pulmonary function and dyspnea, increase exercise tolerance, especially for bronchodilation test positive patients with significant effect. The article published on "Modern Journal of Integrative Medicine".

A total of 52 patients with moderate to severe COPD were enrolled in this study. According to the results of bronchodilation test, the patients were divided into positive group (n = 28) and negative group (n = 24). Two groups of patients were given tiotropium bromide(136310-93-5) powder inhalation, 20μg /d, for 3 months. Pulmonary function, 6-min walk test results (6MWT), and dyspnea scores were statistically analyzed at the beginning and end of the trial.

(FEV1, FEV1%, FVC and FEV1 / FVC), 6MWT and dyspnea score in the positive group were superior to those before treatment (P <0.05); FEV1% and FEV1 / FVC in the negative group (P <0.05), and other lung function indexes and exercise endurance were significantly improved (P <0.05). The improvement of pulmonary function and exercise tolerance of the positive group was better than that of FEV1 (P <0.05), but no significant improvement control group (P <0.05).


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