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Your Yourlocation: Home > Effects of tiotropium bromide(136310-93-5) combined with salmeterol/ fluticasone propionate inhalation on pulmonary function in COPD patients

To investigate the effects of tiotropium bromide(136310-93-5) combined with salmeterol/ fluticasone propionate (50 / 500μg) inhalation on lung function, 6-minute walking distance and adrenocortical function in patients with stable chronic obstructive pulmonary disease (COPD). The study showed that tiotropium bromide(136310-93-5) combined with salmeterol/ fluticasone propionate (50/ 500μg) inhalation therapy can effectively improve COPD patients with lung function and 6MWT, increased exercise tolerance, and the patient's adrenal function has no significant effect, with Good security. The article published on 2015 03  "Zhejiang Medical Journal".

From July 2012 to December 2012, 92 COPD patients were randomly divided into treatment group and control group. The control group received routine treatment with compound Methamidate capsule and ambroxol hydrochloride oral solution. The treatment group was treated with tiotropium bromide(136310-93-5) (1μg/ d), control group Combined salmeterol/ fluticasone propionate (50, 500μg) 1 suction, 2 times/ d. Two groups of continuous treatment for 6 months. (6MWT), first forced expiratory volume (FEV1), first forced expiratory volume (FEV1% pred) and plasma cortisol (FEV1% pred) were measured and compared before and after treatment in both groups. Concentration.

There were no significant differences in FEV1, FEV1% pred (P> 0.05) between the two groups before treatment. The 6-minute walking distance (369.5 ± 52.3) m, FEV1 (1706.4 ± 455.6) m FEV1% pred (58.0 ± 10.5)%, FEV1 (1121.5 ± 492.7) mL and FEV1% pred (37.2 ± 10.3)% in the control group were significantly higher than those in the control group (191.4 ± 61.3) (P <0.01). There was no significant difference in plasma cortisol concentration between the two groups before and after treatment at 8 am (P> 0.05).

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