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Study of salmeterol and tiotropium bromide(136310-93-5) inhalation of tiotropium powder in the treatment of severe, very severe chronic obstructive pulmonary disease in patients with stable clinical efficacy, the study found that the combination of salmeterol and tiotropium powder inhalation powder treatment of severe, very severe COPD patients with stable clinical efficacy, can improve the clinical symptoms in patients with less adverse reactions. This article was published on 2016 06 "Clinical Journal of rational drug use".

The aim of this study was to evaluate the clinical efficacy of salmeterol and tiotropium bromide(136310-93-5) inhalation in the treatment of patients with severe, very stable chronic obstructive pulmonary disease (COPD).

The researchers selected 100 patients with severe COPD stable stage from February 2013 to January 2015 in Shuangliu First People's Hospital. They were randomly divided into study group and control group, 50 cases each. Patients in the control group were treated with salmeterol, and patients in the study group were treated with tiotropium bromide(136310-93-5) powder inhalation on the basis of the control group. The clinical curative effect, the walking distance of 6min before and after treatment and the occurrence of adverse reaction were observed.

The results showed that the total effective rate of the study group was higher than the control group, the difference was statistically significant (P <0.05); before treatment, two groups of patients 6min walking distance, the difference was not statistically significant (P> 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05).

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