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Your Yourlocation: Home > Application of tiotropium bromide(136310-93-5) in children with poor asthma control

To observe the efficacy of tiotropium bromide(136310-93-5), an anticholinergic drug, in children with poor asthma control. Studies have shown that low-dose inhaled corticosteroids inhaled asthma control of children with moderate persistent, the daily addition of a long-acting blocker - tiotropium and the combination of long-acting β2 agonist efficacy equivalent, adverse reactions are rare, can be a poor treatment of asthma in children with alternative options. The article published on 2015 06"Journal of Wuhan University (Medical Sciences)" magazine.

From Jan. 2013 to Jan. 2014, the children with moderate persistent asthma were diagnosed by asthma clinics. According to the revised 2008 Guidelines for the Diagnosis and Prevention of Bronchial Asthma in Children, the clinical evaluation of fluticasone propionate aerosol, 125μg /time, 2 times /d) for 3 months is still assessed as 60 cases of uncontrolled asthma. The rats were randomly divided into two groups: group A (n = 125μg / time) and group B (n = 125μg / time, twice a day) and Formoterol powder inhalation; Group C: Fosplex 125μg / time, 2 times / d + tiotropium bromide(136310-93-5) powder inhalation (Sihua, 18μg 1 times / d), observed for 4 weeks.

There was no significant difference in lung function between group A and group B (P <0.001). The difference of FEV1 and PEF between group B and group C was significant (P <0.001). The clinical symptom scores of the three groups were significantly improved after treatment (P <0.001). The clinical symptom scores of children with asthma control were significantly higher than those of the daytime symptom score (P <0.001) (P <0.05). The clinical symptom score of group C was better than that of group B (P <0.05).

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