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Your Yourlocation: Home > Effects of tiotropium bromide(136310-93-5) bromide on prognosis and serum procalcitonin in patients with moderate to severe chronic obstructive pulmonary disease at stable stage

To observe the effect of tiotropium bromide(136310-93-5) on the prognosis and serum procalcitonin (PCT) in patients with moderate to severe chronic obstructive pulmonary disease (COPD). The study showed that tiotropium bromide(136310-93-5) can reduce the stability of moderate to severe chronic obstructive pulmonary disease in patients with serum procalcitonin, the prognosis is good, should be widely promoted. The article published on 2015 08 "difficult diseases magazine".

A total of 102 patients with COPD admitted between April, 2013 and June, 2015 were randomly divided into observation group (51 cases) and control group (51 cases) according to admission order. 2 groups of patients were treated with conventional therapy, inhaling salbutamol aerosol, infected with antibiotics available, the observation group on the basis of this application of tiotropium bromide(136310-93-5) inhalation 20μg. The pulmonary function index, 4-minute walking distance, dyspnea score and PCT level were compared between the two groups before and after treatment. The changes of the disease and adverse reactions were observed during the treatment.

The incidence of disease progression in the observation group was lower than that in the control group (45.10%) (χ2 = 20.648, P <0.05). After treatment, the FVC of the observation group was (3.21 ± 0.71) L, (1.31 ± 0.31) L (t = 8.218, P = 0.000), and IC (1.32 ± 0.43) L, t = 6.711, P <0.01, (1.95 ± 0.52) L (t = 7.809, P = 0.000) in the observation group and the score of the walking distance and dyspnea in the observation group (397.34 ± 40.12) m and (1.42 ± 0.73) (0.12 ± 0.02) μg / L in the observation group and (0.21 ± 0.04) μg / L in the control group, and the serum PCT of the observation group was (0.12 ± 0.02) μg /L, (0.21 ± 0.04) (P <0.05). In the observation group, there were 2 cases of dry mouth, but all of them were able to tolerate and no serious adverse reactions were observed in the other groups. In the control group, 8 cases of dry mouth, , Palpitations in 1 case, the difference between the two groups was statistically significant (3.9% vs.23.5%, χ2 = 8.279, P <0.05).


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