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Anticholinergic drugs:

The short-acting muscarinic antagonist (SAMA) has a rapid onset of action with about 8 hours of potency and LAMA drugs for 12 to 24 hours. In the improvement of FEV1 with salbutamol named SAMA for ipratropium bromide, increased ipratropium bromide combination of agents can significantly reduce the number of acute exacerbations. Now, tiotropium bromide(136310-93-5) for the LAMA mainstream drugs, its muscarinic receptor 3 high selectivity can make it more significant relaxation of the bronchus.

Ipratropium aerosol, the largest inhalation of 30 to 90 minutes after the maximum effect can be maintained for 6 to 8 hours, the use of the dose of 40 to 80 μg (20 g per spray), 3 to 4 times a day , Adverse reactions.

Tiotropium bromide(136310-93-5), a long-acting anticholinergic, for up to 24 hours at a dose of 18 μg once daily.

The new LAMA includes adefovir, umeclidinium, and glycopyrrolate, with no single-agent formulation. Acetyl bromide antagonizes all of the muscarinic receptors, but rapidly separates from the muscarinic type 2 receptor, which is faster than tiotropium. Umeclidinium (UMEC) medication for the day 1, divided into single-agent and LABA combination preparation of two formulations.


Macrolides can be used in the treatment of COPD because it can play an anti-inflammatory effect. A study of 1,100 patients found that azithromycin 250 mg / day postponed the first acute exacerbation by at least 1 year, but at the same time, these patients were more likely to have hearing loss and macrolide resistance Bacteria colonization.

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