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Your Yourlocation: Home > The effect of tiotropium bromide(136310-93-5) on lung dynamic hyperinflation

In patients with severe to very severe COPD with a history of acute exacerbation who underwent maintenance therapy with tiotropium bromide(136310-93-5) plus a long-acting beta2 agonist, patients who continued to receive inhaled glucocorticosteroid treatment were discontinued, patients with inhaled glucocorticoids have a moderate to severe acute exacerbation.

In previous studies tiotropium bromide(136310-93-5) improved cycle exercise duration in GOLD II-IV COPD patients. This double-blind crossover study (NCT01072396) compared tiotropium with placebo in GOLD I and II COPD using treadmill exercise testing.

Patients were current or ex-smokers aged ≥40 y with post-bronchodilator FEV1/FVC <70%, FEV1 ≥50% predicted, and dynamic hyperinflation (≥100 mL inspiratory capacity [IC] decrease during incremental treadmill exercise). Patients received tiotropium 18 μg qd and placebo for 6 weeks each (random order, 4-week washout). Patients performed constant work rate treadmill exercise at 80% of peak incremental test work rate before and after each treatment period. The primary endpoint was the difference in exercise isotime IC change from baseline to Week 6 between tiotropium bromide(136310-93-5) and placebo. Secondary endpoints included change in exercise duration.

Tiotropium bromide(136310-93-5) was associated with reduced lung hyperinflation at rest and during exercise in GOLD I and II COPD patients. Significantly improved exercise duration was observed in GOLD II patients but not the combined or GOLD I groups.

Many patients with severe or very severe chronic obstructive pulmonary disease may not need the addition of tiotropium bromide(136310-93-5) and long-acting beta2 agonist therapy with inhaled glucocorticoids, which is good news. If so, these patients will be able to circumvent the potential adverse effects associated with inhaled glucocorticoid therapy, including an increased risk of pneumonia and osteoporosis.

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