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Your Yourlocation: Home > Tiotropium bromide(136310-93-5) is an important tool in the management of chronic obstructive pulmonary disease (COPD)

The TIOSPIR study is a large randomized controlled clinical trial of tiotropium. Tiotropium bromide(136310-93-5) is a basic long-acting anti-muscarinic agent, the main route of administration for the use of HandiHaler or Respimat device for inhalation therapy. Both inhalers were manufactured by Boehringer Ingelheim, Connecticut.

Tiotropium bromide(136310-93-5) is an important tool in the management of chronic obstructive pulmonary disease (COPD), an earlier large randomized controlled trial that underestimates its value. The UPLIFT study led to a relatively clear understanding of the role of the drug in reducing acute exacerbations in patients with COPD.

After the UPLIFT study, some meta-analyzes concluded conflicting conclusions about the safety of tiotropium bromide(136310-93-5) (whether using the currently used HandiHaler inhaler or the new Respimat inhaler). The focus of the debate is on the heart of tiotropium Vascular toxicity.

Cardiovascular safety of tiotropium bromide(136310-93-5) has been a concern before UPLIFT, and UPLIFT as a placebo-controlled trial did not show signs of tiotropium's cardiovascular toxicity. However, several meta-analyzes later suggested that no cardiovascular toxicity of tiotropium was found with the HandiHaler device, which may be related to the use of the Respimat device.

The Respimat device uses a different technique than the HandiHaler inhaler to allow more medication to reach the patient's lungs, and therefore the systemic absorption of the drug may be greater. This statement appears to provide a possible biological explanation or support for the hypothesis that the Respimat device has a security problem.

To address this problem, the TIOSPIR study group randomly assigned patients with COPD to 3 groups: low-dose tiotropium Respimat, high-dose tiotropium Respimat, and standard-dose tiotropium, HandiHaler, with an average follow-up Time is 2.3 years.

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